# GLP-1.app

> GLP-1 research, explained: plain-English summaries of published clinical trials and guidelines on GLP-1 medicines (semaglutide, tirzepatide). Every figure links to its primary source (NEJM, Lancet, JAMA, PubMed). Written by the team behind Beanly, a GLP-1 companion app. Not medical advice; not affiliated with any drug maker.

Each article states the trial population, the key results with numbers, side effects, and what the findings do and do not show. A full-text version of every article is at https://glp-1.app/llms-full.txt.

## Trial results

- [What happens when you stop a GLP-1? What three trials found about weight regain](https://glp-1.app/stopping-glp-1-weight-regain/): STEP 1, STEP 4 and SURMOUNT-4 followed people who stopped semaglutide or tirzepatide. Here is how much weight came back, how fast, and what it means.
- [How much weight do people lose on oral semaglutide? What the OASIS trials found](https://glp-1.app/oral-semaglutide-weight-loss/): OASIS 1 and OASIS 4 tested daily semaglutide pills for weight loss. Here is how much weight people lost, how it compares with the weekly shot, and side effects.
- [How much weight do people lose on GLP-1 medication? What STEP 1 and SURMOUNT-1 found](https://glp-1.app/glp-1-weight-loss-results/): The two landmark trials behind Wegovy and Zepbound, in plain English: average weight loss, how many people reached 10% or 20%, side effects and what the averages hide.
- [How much weight do people with type 2 diabetes lose on a GLP-1? What STEP 2 and SURMOUNT-2 found](https://glp-1.app/glp-1-type-2-diabetes-weight-loss/): STEP 2 and SURMOUNT-2 tested semaglutide 2.4 mg and tirzepatide for weight loss in adults with type 2 diabetes. Here are the results and how they compare.
- [Does GLP-1 weight loss last? What two- and three-year trials found](https://glp-1.app/glp-1-long-term-results/): STEP 5 followed semaglutide for two years and SURMOUNT-1 followed tirzepatide for three. Here is whether weight stayed off and what happened to diabetes risk.

## Comparisons

- [Semaglutide vs tirzepatide: which leads to more weight loss? What the head-to-head trial found](https://glp-1.app/semaglutide-vs-tirzepatide/): SURMOUNT-5 compared tirzepatide and semaglutide head to head for 72 weeks in 751 adults with obesity. The weight, waist and side-effect results, plus caveats.

## Nutrition

- [How much protein do you need on a GLP-1? What the research says about protecting muscle](https://glp-1.app/protein-on-glp-1/): Part of the weight lost on semaglutide and tirzepatide is lean mass. Here is what the trials measured, what the 2025 nutrition advisory suggests for protein, and a quick calculator.

## Health conditions

- [Can tirzepatide help sleep apnea? What the SURMOUNT-OSA trials found](https://glp-1.app/glp-1-sleep-apnea/): Two SURMOUNT-OSA trials tested tirzepatide in adults with obesity and moderate-to-severe sleep apnea. Here is what AHI means and how much it changed in a year.
- [Does semaglutide help knee osteoarthritis pain? What the STEP 9 trial found](https://glp-1.app/glp-1-knee-osteoarthritis/): STEP 9 tested semaglutide in adults with obesity and painful knee osteoarthritis. Here is what happened to weight, pain and physical function over 68 weeks.
- [Does semaglutide lower the risk of heart attack and stroke? What the SELECT trial found](https://glp-1.app/glp-1-heart-select-trial/): SELECT followed 17,604 adults with heart disease and overweight or obesity but no diabetes. What semaglutide 2.4 mg did to heart attacks, strokes and weight.
- [Can GLP-1 medicines help fatty liver disease (MASH)? What the trials found](https://glp-1.app/glp-1-fatty-liver/): Semaglutide's phase 3 ESSENCE trial and tirzepatide's phase 2 SYNERGY-NASH trial checked liver biopsies in people with MASH. Here is what changed, in plain words.

## Side effects

- [How common is nausea on a GLP-1, and how long does it last? What the research says](https://glp-1.app/glp-1-side-effects-nausea/): Nausea, diarrhea, vomiting and constipation on semaglutide and tirzepatide: how often they happened in trials, when they peaked, and what helped.
- [Does semaglutide or tirzepatide cause hair loss? What the research says](https://glp-1.app/glp-1-hair-loss/): How often hair loss was reported in GLP-1 trials, why rapid weight loss is the leading explanation, and what is still unknown about the cause.

## Optional

- [About and editorial policy](https://glp-1.app/about/): who writes the site and how sources are chosen
- [Beanly on Google Play](https://play.google.com/store/apps/details?id=com.minhtruong.beanly): companion app for protein, weight and weekly doses